4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, >=98%, powder

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, >=98%, powder

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Application


4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.


General description


4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.


Packaging


5 mg in glass bottle


25, 100 mg in poly bottle

Quality Level200
mp180-182 °C (lit.)
InChI keyJJAHTWIKCUJRDK-UHFFFAOYSA-N
InChI1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98%

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