Spermine tetrahydrochloride, BioReagent, for molecular biology
Application
Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
General description
Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
| Quality Level | 300 |
|---|---|
| mp | 310-311 °C (dec.) (lit.) |
| InChI key | XLDKUDAXZWHPFH-UHFFFAOYSA-N |
| InChI | 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H |
| Manufacturer | SIGMA-ALDRICH |
| Product Line | BioReagent |
| Form | solid |
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