Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology
Application
Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
General description
Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.
Chemical structure: macrolide
Packaging
5, 25 mg in glass bottle
Principle
Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.
| InChI key | KQNZDYYTLMIZCT-KQPMLPITSA-N |
|---|---|
| InChI | 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥99% (HPLC and TLC) |
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