Tn Antigen, >=99.0% (TLC)
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
General description
Tn antigenis a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
| Quality Level | 100 |
|---|---|
| InChI key | REDMNGDGDYFZRE-WKWISIMFSA-N |
| InChI | 1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Form | powder or crystals |
| Assay | ≥99.0% (TLC) |
There are no downloads for this product.
