Cortistatin-14, >=97% (HPLC)
Application
Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).
Biochem/physiol Actions
Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.
Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.
General description
Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. In the peripheral system, it is produced in adrenal, thyroid, parathyroid, stomach, intestine, pancreas, testes, liver and kidney.
| Quality Level | 200 |
|---|---|
| InChI key | DDRPLNQJNRBRNY-WYYADCIBSA-N |
| InChI | 1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84) |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥97% (HPLC) |
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