4-Bromo-calcium Ionophore A23187, powder
Application
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
Biochem/physiol Actions
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
Other Notes
Analog of calcium ionophore A23187
Packaging
1 mg in glass bottle
| Colour | yellow |
|---|---|
| Quality Level | 200 |
| InChI key | LDXQFZZGVTWFCF-FHYGWRBKSA-N |
| InChI | 1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | ethanol: 20 mg/mL, DMSO: soluble |
| Form | powder |
There are no downloads for this product.
