3-Aminopropionitrile fumarate salt, metabolite
Application
3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:to inhibit collagen cross-linking during microtissue formation and culturein LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assayin lysyl oxidase (LOX) activity assayto study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids
Biochem/physiol Actions
3-Aminopropionitrile (?-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.
In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.
Packaging
5, 10, 25 g in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 177 °C (dec.) (lit.) |
| InChI key | NYMXYZMHOZAPHQ-SEPHDYHBSA-N |
| InChI | 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;; |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (TLC) |
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