PRALATREXATE
Biochem/physiol Actions
Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DHFR (dihydrofolate reductase).
| Colour | white to beige |
|---|---|
| InChI key | OGSBUKJUDHAQEA-WMCAAGNKSA-N |
| InChI | 1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,3 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | DMSO: 2 mg/mL |
| Form | powder |
| Assay | ≥98% (HPLC) |
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