CELGOSIVIR
Biochem/physiol Actions
Celgosivir is a prodrug of natural bicyclic iminosugar castanospermine that exhibits antiviral activity in vivo including HCV and dengue. Celgosivir is an inhibitor of α-glucosidases, which inhibits glycoprotein processing in cell culture. Apparently inhibition of α-glucosidases within infected cell prevents secretion of virus.
| Colour | white to beige |
|---|---|
| InChI key | HTJGLYIJVSDQAE-VWNXEWBOSA-N |
| InChI | 1S/C12H21NO5/c1-2-3-9(15)18-8-6-13-5-4-7(14)10(13)12(17)11(8)16/h7-8,10-12,14,16-17H,2-6H2,1H3/t7-,8-,10+,11+,12+/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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