1S;3R-RSL 3
Application
1S,3R-RSL 3 has been used:as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) linesGPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in miceas a ferroptosis inducer in HT-1080 cellsin cell viability assay
Biochem/physiol Actions
RSL3 is an inducer of ferroptosis. It acts by a different method than erastin to induce ferroptosis by inhibiting glutathione peroxidase 4 (GPX4).
| Colour | white to beige |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | DMSO: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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