RWJ 67657

Descriptions

Biochem/physiol Actions

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and IL-1β from LPS induced blood mononuclear cells. It exhibits cardioprotective and anti-inflammatory activities in vivo.

Specifications

Colour	white to beige
InChI key	QSUSKMBNZQHHPA-UHFFFAOYSA-N
InChI	1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
Manufacturer	SIGMA-ALDRICH
Storage Temp.	2-8°C
Solubility	DMSO: 2 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)