NCT-503 INACTIVE CONTROL
Application
NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.
Biochem/physiol Actions
NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC50 value >57 µM for PHGDH. NCT-503 has an IC50 value of 2.5 µM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.
Packaging
5, 25 mg in glass bottle
Recommended products
The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | ITLPIAAGIQAGRA-UHFFFAOYSA-N |
| InChI | 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 5 mg/mL, clear (warmed) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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