GEMIFLOXACIN MESYLATE
Biochem/physiol Actions
Gemifloxacin is a broad-spectrum quinolone antibacterial. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Gemifloxacin is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. Gemifloxacin has also been found to inhibit migration and invasion of human colon cancer cells.
Packaging
5, 25 mg in glass bottle
| Colour | white to light brown |
|---|---|
| Quality Level | 100 |
| InChI key | JIYMVSQRGZEYAX-CWUUNJJBSA-N |
| InChI | 1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: 10 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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