SITAMAQUINE TOSYLATE
Biochem/physiol Actions
Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities. Sitamaquine accumulates in Leishmania parasites. Sitamaquine potently inhibits respiratory chain complex II (succinate dehydrogenase), which leads to an apoptosis-like death of Leishmania parasites.
Sitamaquine is also known as WR-6026. It is used in the treatment of visceral leishmaniasis.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | LOBPWLFCZDGYKW-UHFFFAOYSA-N |
| InChI | 1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: 15 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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