MARINOPYRROLE A
Biochem/physiol Actions
Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737.
General description
Marinopyrrole A (Maritoclax) is a member of phenolic 1,3?-bipyrroles family targeting actin group.
Packaging
5, 25 mg in glass bottle
| Colour | light yellow to dark yellow |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | DMSO: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥95% (HPLC) |
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