Biochem/physiol Actions
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.
Packaging
5, 25 mg in glass bottle
| Colour | white to brown |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: 5 mg/mL, clear (warmed) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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