TENATOPRAZOLE

Descriptions

Biochem/physiol Actions

Tenatoprazole is used to maintain high diurnal and nocturnal pH levels. It prevents gastric H⁺,K⁺-ATPase with potency similar to omeprazole.

Tenatoprazole is a proton pump inhibitor. Tenatoprazole is an acid-activated prodrug that binds covalently to gastric H,K-ATPase, resulting in acid secretion inhibition. Tenatoprazole has a different structural class from omeprazole and most other proton pump inhibitors, with an imidazopyridine backbone rather than benzimidazole, which results in slower metabolism. Tenatoprazole thus has a long plasma half-life as compared to omeprazole, resulting in prolonged inhibition of acid secretion.

General description

Tenatoprazole is a novel proton pump inhibitor with an imidazopyridine backbone. It has seven-fold longer plasma half-life. It is also called as 5-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-imidazo[4,5-b]pyridine.Tenatoprazole is a member of the class of covalent proton pump inhibitors.

Packaging

10, 50 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	ZBFDAUIVDSSISP-UHFFFAOYSA-N
InChI	1S/C16H18N4O3S/c1-9-7-17-12(10(2)14(9)23-4)8-24(21)16-18-11-5-6-13(22-3)19-15(11)20-16/h5-7H,8H2,1-4H3,(H,18,19,20)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)