MADRASIN

Stock Code: 3574875
Manufacturer Part No: SML1409-25MG

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Descriptions

Application

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.

Biochem/physiol Actions

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.

Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	, white to dark brown
Quality Level	100
InChI key	QQJIYKXTEMDJFM-UHFFFAOYSA-N
InChI	1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 0.5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)