Biochem/physiol Actions
YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC50 = 7 µM), and does not inhibit intracellular PLA2 isoforms.
YM-26734 is a natural product analog and a derivative of YM-26567-1, which is found in the fruit ofHorsfieldia amygdaline. It exhibits a broad inhibitory spectrum towards different sPLA2s.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | CEJAYJCUSZHYDS-UHFFFAOYSA-N |
| InChI | 1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥95% (HPLC) |
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