Biochem/physiol Actions
IWP-4 is a potent inhbitor of the Wnt pathway regulatory protein porupine (Porcn). IWP-4 blocks palmitylation, and subsquent secretion and activity of Wnt. IWP-4 induces the differentiation of human pluripotent stem cells into cardiomyocytes.
IWP-4 blocks Wnt family member 5a. It blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways.
Packaging
5, 25 mg in glass bottle
| Colour | white to light brown |
|---|---|
| Quality Level | 100 |
| InChI key | RHUJMHOIQBDFQR-UHFFFAOYSA-N |
| InChI | 1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 0.5 mg/mL, clear (warmed) |
| Form | powder |
| Assay | ≥95% (HPLC) |
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