DIAPOCYNIN

Descriptions

Biochem/physiol Actions

Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson’;s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD.

Diapocynin is a covalent dimer of apocynin, and a functional metabolite of the same. It is generated by neutrophil activation via myeloperoxidase-mediated oxidation. Studies show that diapocynin has greater neuroprotection compared to apocynin.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
Manufacturer	SIGMA-ALDRICH
Storage Temp.	room temp
Solubility	DMSO: 2 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)