SANT-1, >=98% (HPLC), powder

Descriptions

Application

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death.

Biochem/physiol Actions

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-?B pathway in glioblastoma cells.

Packaging

5, 25 mg in glass bottle

Specifications

Quality Level	100
InChI key	FOORCIAZMIWALX-JJIBRWJFSA-N
InChI	1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
Manufacturer	SIGMA-ALDRICH
Storage Temp.	−20°C
Solubility	DMSO: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)