CP-456773 Sodium Salt
Application
CP-456773 sodium salt has been used : In in vivo experiments to study the neuroprotective action of ketogenic diet. To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.
Biochem/physiol Actions
CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.
CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1? and IL-18. It is also referred to as MCC950.
Legal Information
Pfizer is a registered trademark of Pfizer, Inc.
Sold for research purposes under agreement from Pfizer Inc.
Other Notes
This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | LFQQNXFKPNZRFT-UHFFFAOYSA-M |
| InChI | 1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | room temp |
| Solubility | H2O: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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