NSCI, >=97% (HPLC), solid
Application
NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) T cells from pleural effusions, mononuclear cells (PEMCs).
Biochem/physiol Actions
1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
5, 25 mg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | XDHJBIYJRNFDKS-IBGZPJMESA-N |
| InChI | 1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-1 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: >10 mg/mL, H2O: insoluble |
| Form | solid |
| Assay | ≥97% (HPLC) |
There are no downloads for this product.
