CI 976, , >98% (HPLC), solid
Application
CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells to treat Neuro-2a cells to test its effect on plasma membrane integrated density of ?4-SEP?2 or ?6-SEP?2?3 nicotinic acetylcholine receptors (nAChRs)to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells
Biochem/physiol Actions
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.
Packaging
5 mg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | WAFNZAURAWBNDZ-UHFFFAOYSA-N |
| InChI | 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25) |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: >10 mg/mL, H2O: insoluble ﹤2 mg/mL |
| Form | solid |
| Assay | >98% (HPLC) |
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