Chromeceptin, >=98% (HPLC), solid
Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.
Features and Benefits
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
5, 25 mg in glass bottle
| Colour | yellow to brown |
|---|---|
| Quality Level | 100 |
| InChI key | GVINXTXGDDSXFQ-UHFFFAOYSA-N |
| InChI | 1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: ﹤2 mg/mL, DMSO: >20 mg/mL |
| Form | solid |
| Assay | ≥98% (HPLC) |
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