Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3,5-cyclic monophosphorothioate sodium salt, >=98% (HPLC
Biochem/physiol Actions
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
U.S. Patent 5,625,056, DE Patent 4,217,679.
Packaging
1, 5 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| mp | 240-300 °C (lit.) |
| InChI key | SVMPQLHYWRTQCX-DBHVCDLJSA-M |
| InChI | 1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,2 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (HPLC) |
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