MONOCLONAL MESOTHELIN (EP140)
General description
Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.1 Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.1, 3-4 Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.2, 4-6 Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.4-6?
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
Linkage
Mesothelin Positive Control Slides, Product No. 439S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Other Notes
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Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.
Preparation Note
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Quality
| IVD | IVD | IVD | RUO |
| Quality Level | 100; 500 |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Further Info | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| Storage Temp. | 2-8°C |
| Form | buffered aqueous solution |
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