MONOCLONAL PAX-5 (24)
General description
PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5. PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation. Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
Linkage
PAX-5 Positive Control Slides, Product No. 312S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Other Notes
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Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide
Preparation Note
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Quality
| IVD | IVD | IVD | RUO |
| Quality Level | 100; 500 |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Further Info | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| Storage Temp. | 2-8°C |
| Form | buffered aqueous solution |
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