Transferrin human, powder, BioReagent, suitable for cell culture
Analysis Note
Purity by agarose electrophoresis.
Application
Transferrin human has been used:to incubate human proximal tubule cells (HKC) - 8 cells along with IgG for the examination of albumin specificityas a supplement in serum-containing/devoid medium for human thyroid cell cultureas a target glycoprotein to develop an in-gel hydrazinolysis method
Biochem/physiol Actions
Transferrin mediates iron transportation from plasma to cells. The iron-bound transferrin are of three forms: monoferric A/B transferrin and diferric transferrin. The transferrin binds to specific cell surface receptors and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded. Transferrin is known to deliver iron to cells in a physiologically safe and effective form.
General description
Transferrin is a glycoprotein with a branched carbohydrate chain, having two sites for ferric ion binding in its polypeptide chain.
Other Notes
Partially iron-saturated
Preparation Note
Heat treated at 60 °C for ten hours.
| Quality Level | 200 |
|---|---|
| Pack | 1G |
| Manufacturer | SIGMA-ALDRICH |
| Product Line | BioReagent |
| Impurities | endotoxin, tested, hepatitis and HIV antibody, none detected |
| Form | powder |
| Assay | ≥98% |
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