Aminopterin, powder, BioReagent, suitable for cell culture
Application
Aminopterin has been used in the production of anti- neurogranin antibodies.
Biochem/physiol Actions
Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
Aminopterin is found to inhibit growth, embryogenesis and has toxic effects in mice models. It serves as a abortifacient. Aminopterin is known to reduce the effects of acute leukemia in children.
Linkage
More potent, but more toxic, than methotrexate.
| Colour | yellow |
|---|---|
| Pack | 10MG |
| InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N |
| InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)( |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥97% |
There are no downloads for this product.
