MONOCLONAL ISLET-1 (EP283)

Descriptions

General description

Islet-1, a human insulin gene enhancer-binding protein, is a transcription factor involved in the differentiation of the neuroendocrine pancreatic cells.^1-3 Islet-1 plays an important role in the embryogenesis and differentiation of the insulin producing pancreatic beta cells within the islets of Langerhans.³ Neuroendocrine tumors can arise from a variety of primary sites, most commonly in the bronchopulmonary system, gastrointestinal (GI) tract, and pancreas.² Neuroendocrine tumors of the GI tract and pancreas tend to be slow growing and indolent, and may metastasize to the liver before it is detected.² Islet-1 exhibits strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumor.^1-3 Islet-1 has been shown to be a reliable marker for the detection of primary and metastatic pancreatic neuroendocrine neoplasms.^1-3

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Islet-1 Positive Control Slides, Product No. 431S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Quality

IVD

RUO

Specifications

No detailed specifications are available for this product.

Downloads

There are no downloads for this product.

Code	Description	Quality Level	Manufacturer	Further Info	Storage Temp.	Form	Price	Quantity
3573050	MONOCLONAL ISLET-1 (EP283)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£273.04 (exc VAT) per EACH	- +
3573051	MONOCLONAL ISLET-1 (EP283)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£700.50 (exc VAT) per EACH	- +
3573052	MONOCLONAL ISLET-1 (EP283)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£1,093.81 (exc VAT) per EACH	- +
3573053	MONOCLONAL ISLET-1 (EP283)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£256.79 (exc VAT) per EACH	- +
3573054	MONOCLONAL ISLET-1 (EP283)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£706.99 (exc VAT) per EACH	- +